Modelling afferent nerve responses to bladder filling
نویسندگان
چکیده
Maryam Argungu, Saziye Bayram, Bindi Brook, Buddhapriya Chakrabarti, Richard H Clayton, Donna M Daly, Rosemary J Dyson, Craig Holloway, Varun Manhas, Shailesh Naire, Tom Shearer, and Radostin Simitev Department of Bioengineering, Imperial College London, London, UK Department of Mathematics, SUNY Buffalo State, Buffalo NY, USA School of Mathematical Sciences, University of Nottingham, Nottingham, UK Department of Mathematical Sciences, Durham University, Durham, UK Department of Computer Science, University of Sheffield, Sheffield, UK Department of Biomedical Science, University of Sheffield, Sheffield, UK School of Mathematics, University of Birmingham, Birmingham, UK Biomedical Engineering, University of Liége & KU Leuven, Leuven, Belgium School of Computing and Mathematics, Keele University, Keele, UK School of Mathematics University of Manchester, Manchester, UK School of Mathematics and Statistics, University of Glasgow, Glasgow, UK (Dated: October 13, 2015)
منابع مشابه
AB320. SPR-47 Monitoring nerve activity during bladder filling in a rat model
Objective: Surgical rerouting of neuronal pathways may allow functional reinnervation of the bladder. We aim to develop techniques to monitor afferent (sensory) nerve activity during bladder filling in normal intact bladders for eventual application to monitoring sensory reinnervation of the bladder following nerve transfer. Methods: Electroneurogram recordings were performed in anesthetized ra...
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Activation of afferent nerves during urinary bladder (UB) filling conveys the sensation of UB fullness to the central nervous system (CNS). Although this sensory outflow is presumed to reflect graded increases in pressure associated with filling, UBs also exhibit nonvoiding, transient contractions (TCs) that cause small, rapid increases in intravesical pressure. Here, using an ex vivo mouse bla...
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Much attention has been given to the pelvic nerve afferent innervation of the urinary bladder; however, reports differ considerably in descriptions of afferent receptor types, their conduction velocities, and their potential roles in bladder reflexes and sensation. The present study was undertaken to do a relatively unbiased sampling of bladder afferent fibers of the pelvic nerve in adult femal...
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Social stress has been implicated as a cause of urinary bladder hypertrophy and dysfunction in humans. Using a murine model of social stress, we and others have shown that social stress leads to bladder overactivity. Here, we show that social stress leads to bladder overactivity, increased bladder compliance, and increased afferent nerve activity. In the social stress paradigm, 6-wk-old male C5...
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BACKGROUND Phosphodiesterase type 5 inhibitors (PDE5-Is) improve storage symptoms in benign prostatic hyperplasia patients, despite a lack of effect on peak urinary flow rate. Moreover, vardenafil improves urodynamic parameters in spinal cord-injured (SCI) patients with neurogenic detrusor overactivity (NDO). SCI rats also display NDO characterized by nonvoiding contractions (NVCs) during bladd...
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Our goal was to develop and refine a decerebrate arterially perfused rat (DAPR) preparation that allows the complete bladder filling and voiding cycle to be investigated without some of the restrictions inherent with in vivo experimentation [e.g., ease and speed of set up (30 min), control over the extracellular milieu and free of anesthetic agents]. Both spontaneous (naturalistic bladder filli...
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